The game shares the same fictional universe with Earnest Evans, and happens several years later.
New York City, 1928. A mad religious leader known as Henry seeks to awaken the ancient and malevolent god Hastur. A sorceress named Restiana offers herself to Henry as a sacrifice for a cause which will bring the inevitable down fall of mankind.
There are some people that have descended from Hastur’s ancient bloodline, one of which is the young Peruvian sorceress, Annet Myer. With some assistance from Earnest Evans, Annet attempts to stop the cult from resurrecting Hastur using the very spells of this bloodline.